讲授课程

放射性药物化学基础，放射性药物化学实验，化学基础实验1，放射性药物与分子影像

研究兴趣

放射性药物、分子探针与分子影像

主持项目

1. 2012.1-2015.12，国家自然科学基金青年项目

2. 2014.1-2015.6，北京市自然科学基金预探索项目

3. 2014.1-2017.12，国家重大新药创制子课题

4. 2016.1-2019.12，国家自然科学基金面上项目

5. 2018.1-2020.12，北京市自然科学基金面上项目

6. 2020.1-2023.12，国家自然科学基金联合基金重点项目

7. 2021.1-2023.12，国家自然科学基金优秀青年基金项目

代表性论文

1.  Zhou, Kaixiang; Yuan, Chang; Dai, Bin; Wang, Kan; Chen, Yimin; Ma, Denglei; Dai, Jiapei; Liang, Yi*; Tan, Hongwei*; Cui, Mengchao*, Environment-Sensitive Based Near-Infrared Probe for Fluorescent Discrimination of Aβ and Tau Fibrils in AD Brain, J. Med. Chem., 2019, 62(14): 6694-6704
   

2. Zhang, Xiaoyang; Hou, Yaqin; Peng, Cheng; Wang, Chu; Wang, Xiang; Liang, Zhigang*; Lu, Jing; Chen, Baian*; Dai, Jiapei; Liu, Boli; Cui, Mengchao*, Oligoethyleneoxy-Modified 99mTc-Labeled β‑Amyloid Imaging Probes with Improved Brain Pharmacokinetics for Single-Photon Emission Computed Tomography, J. Med. Chem., 2018, 61(3): 1330-1339

3. Fu, Hualong; Cui, Mengchao*; Zhao, Liu; Tu, Peiyu; Zhou, Kaixiang; Dai, Jiapei; Liu, Boli, Highly Sensitive Near-Infrared Fluorophores for in Vivo Detection of Amyloid-beta Plaques in Alzheimer's Disease, J. Med. Chem., 2015, 58(17): 6972-6983

4. Yang, Yanping; Cui, Mengchao*; Zhang, Xiaoyang; Dai, Jiapei; Zhang, Zhiyong; Lin, Chunping; Guo, Yuzhi; Liu, Boli, Radioiodinated Benzyloxybenzene Derivatives: A Class of Flexible Ligands Target to β-Amyloid Plaques in Alzheimer's Brains, J. Med. Chem., 2014, 57(14): 6030-6042

5. Li, Zijing; Cui, Mengchao*; Dai, Jiapei; Wang, Xuedan; Yu, Pingrong; Yang, Yanping; Jia, Jianhua; Fu, Hualong; Ono, Masahiro; Jia, Hongmei; Saji, Hideo; Liu, Boli*, Novel Cyclopentadienyl Tricarbonyl Complexes of Tc-99m Mimicking Chalcone as Potential Single-Photon Emission Computed Tomography Imaging Probes for β-Amyloid Plaques in Brain, J. Med. Chem., 2013, 56(2): 471-482

6. Cui, Mengchao; Ono, Masahiro*; Kimura, Hiroyuki; Ueda, Masashi; Nakamoto, Yuji; Togashi, Kaori; Okamoto, Yoko; Ihara, Masafumi; Takahashi, Ryosuke; Liu, Boli; Saji, Hideo, Novel F-18-Labeled Benzoxazole Derivatives as Potential Positron Emission Tomography Probes for Imaging of Cerebral β-Amyloid Plaques in Alzheimer's Disease, J. Med. Chem., 2012, 55(21): 9136-9145

7. Cui, Mengchao*; Wang, Xuedan; Yu, Pingrong; Zhang, Jinming; Li, Zijing; Zhang, Xiaojun; Yang, Yanping; Ono, Masahiro; Jia, Hongmei; Saji, Hideo; Liu, Boli*, Synthesis and Evaluation of Novel F-18 Labeled 2-Pyridinylbenzoxazole and 2-Pyridinylbenzothiazole Derivatives as Ligands for Positron Emission Tomography (PET) Imaging of β-Amyloid Plaques, J. Med. Chem., 2012, 55(21): 9283-9296. (Cover Article)

8. Cui, Mengchao; Ono, Masahiro*; Kimura, Hiroyuki; Liu, Boli; Saji, Hideo*, Synthesis and Structure-Affinity Relationships of Novel Dibenzylideneacetone Derivatives as Probes for β-Amyloid Plaques, J. Med. Chem., 2011, 54(7): 2225-2240

授权专利

1. 202010182851.8靶向PSMA的双苯并噻二唑类化合物及其制备方法与应用

2. 201910007703.X与Aβ蛋白和Tau蛋白具有高亲和力的双腙类化合物及其衍生物与应用

3. 201811565327.8一种氟硼二吡咯类衍生物及其制备方法和用途

4. 201710702980.3用于生物正交反应的1,2,4,5‑四嗪化合物及其制备方法与应用 

5. 201711144219.9与Tau蛋白具有亲和力的2-芳基喹喔啉类化合物及其制备方法与应用

6. 201710474957.3与Aβ斑块具有高亲和力的二苯氧基柔性分子及其制备方法和应用

7. 201410307344.7与Aβ斑块和神经纤维缠结具有亲和力的化合物及制备方法

8. 201310447043.X与Aβ斑块具有高亲和力的2-芳基苯并噻唑类化合物、其制备方法及应用

9. US 9,809,585 B2 Fluorinated 2-arylbenzo heterocyclic compound with high affinity to Aβ plaques and containing chiral side chain substituent, and preparation method and usage thereof

10. WO/2013/027694 Molecular imaging probes for diagnosing conformation disease