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贾红梅 教授，博士生导师，理学博士（金沙威尼斯欢乐娱人城），美国耶鲁大学访问学者，德国亥姆霍兹Dresden‒Rossendorf研究中心高级研究学者，德国莱比锡多学科综合同位素研究院访问学者和高级访问学者。国际同位素学会(IIS)官方期刊《Journal of Labelled Compounds and Radiopharmaceuticals》的亚洲编辑、国际放射性药物科学学会(SRS)官方期刊《Nuclear Medicine and Biology》和欧洲期刊《EJNMMI Radiopharmacy and Chemistry》编委等。 通信地址：北京市新街口外大街19号 金沙威尼斯欢乐娱人城 邮编：100875 电话：010 5880 7843； 传真：010 5880 2750 电子邮箱: hmjia@bnu.edu.cn |
讲授课程
放射性药物化学，普通化学实验
研究兴趣
放射性药物化学，生物功能显像分子探针的研究。
主持的科研项目
1. 针对神经炎症的靶向小胶质细胞集落刺激因子1受体的PET显像分子探针研究，2023.1-2026.12，国家自然科学基金项目（22276016）；
2. 用于阿尔茨海默病诊断和治疗效果评价的sigma-2受体分子探针，2019.1-2022.12，国家自然科学基金项目（21876013）；
3. 18F标记的sigma-1受体分子探针和阿尔茨海默病进程中的可视化研究，北京市自然科学基金项目（7212203）；
4. 用于肿瘤诊断和个性化治疗的Tc-99m/Re-188标记的s2受体放射性药物研究，2015.1−2018.12，国家自然科学基金项目（21471019）；
5. Tc-99m标记的s2受体肿瘤分子探针的研究，2010.1−2013.12，国家自然科学基金项目（21071023）；
6. Tc-99m标记的s受体肿瘤显像剂的研究，2006.1−2008.12，国家自然科学基金项目（20501004）；
7. 还原醚化反应及其在F-18标记的PET放射性药物合成中的应用研究，教育部留学回国人员科研启动基金；
8. 肿瘤显像与治疗，2013.4−2013.10，国家自然科学基金国际合作与交流项目（21310102012）；
9. Sigma受体分子探针的研究，2011.10−2011.11，国家自然科学基金国际合作与交流项目（21110102042）；
10. Sigma受体显像剂的研究，2008.10.19−2008.10.26，国家自然科学基金国际合作与交流项目（20810102039）；
11. Sigma受体显像剂的生物评价方法，2007.10，国家自然科学基金国际合作与交流项目。
专利
1. 贾红梅、何颖芳、谢芳、陆洁、黄艺耘。结合sigma-1受体的四羟基糠基哌嗪类化合物、其制备方法及应用。中国，专利号ZL 2016 1 0509926.2。授权公告日：2018年10月23日。
2. 贾红梅，王霞，李丹，崔孟超，刘伯里. 结合sigma-1受体的三羰基环戊二烯类配体化合物、其制备方法及应用. 专利号: ZL 2013 1 0339656.1授权公告日：2016年4月6日.
3. 贾红梅，李艳，张锦明，崔孟超，刘伯里. 氟-18标记的螺环哌啶类sigma-1受体化合物及制备方法和应用. 专利号: ZL 2012 1 0097119.6. 授权公告日：2014年10月08日.
代表性论文
1. Zhang Ying, Wang Tao, Zhang Xiaojun, Deuther-Conrad Winnie, Fu Hualong, Cui Mengchao, Zhang Jinming*, Brust Peter, Huang Yiyun*, Jia Hongmei*. Discovery and development of brain-penetrant 18F-labeled radioligands for neuroimaging of the sigma-2 receptors. Acta Pharmaceutica Sinica B, 2022, 12(3): 1406-1415.
2. Wang Tao, Zhang Ying, Zhang Xiaojun, Chen Leyuan, Zheng Ming-Qiang, Zhang Jinming*, Brust Peter, Deuther-Conrad Winnie, Huang Yiyun*, Jia Hongmei*. Synthesis and characterization of the two enantiomers of a chiral sigma-1 receptor radioligand: (S)-(+)- and (R)-(-)-[18F]FBFP. Chinese Chemical Letters, 2022, 33(7): 3543-3548.
3. Jia Hongmei*, Cai Zhengxin, Holden Daniel, He Yingfang, Lin Shu-fei, Li Songye, Baum Evan, Shirali Anupama, Kapinos Michael, Gao Hong, Ropchan Jim, Huang Yiyun*. Positron emission tomography imaging evaluation of a novel 18F-labeled sigma-1 receptor radioligand in cynomolgus monkeys. ACS Chemical Neuroscience, 2020, 11: 1673−1681.
4. Tian Jiale, He Yingfang, Deuther-Conrad Winnie, Fu Hualong, Xie Fang, Zhang Ying, Wang Tao, Zhang Xiaojun, Zhang Jinming*, Brust Peter, HuangYiyun, Jia Hongmei*. Synthesis and evaluation of new 1-oxa-8-azaspiro[4.5]decane derivatives as candidate radioligands for sigma-1 receptors. Bioorganic & Medicinal Chemistry, 2020, 28: 115560.
5． He Yingfang, Xie Fang, Ye Jiajun, Deuther-Conrad Winnie, Cui Bixiao, Wang Liang, Lu Jie, Steinbach Jörg, Brust Peter, Huang Yiyun, Lu Jie*, Jia Hongmei*. 1-(4-[18F]Fluorobenzyl)-4-((tetrahydrofuran-2-yl) methyl)piperazine: A novel suitable radioligand with low lipophilicity for imaging σ1 receptors in the brain. Journal of Medicinal Chemistry, 2017, 60: 4161-4172.
6. Wang Liang, Ye Jiajun, He Yingfang, Deuther-Conrad Winnie, Zhang Jinming, Zhang Xiaojun, Cui Mengchao*, Steinbach Jörg, Huang Yiyun, Brust Peter, Jia Hongmei*. 18F-Labeled indole-based analogs as highly selective radioligands for imaging sigma-2 receptors in the brain. Bioorganic & Medicinal Chemistry, 2017, 25: 3792–3802.
7. Li Dan, Chen Yuanyuan, Wang Xia, Deuther-Conrad Winnie, Chen Xin, Jia Bing, Dong Chengyan, Steinbach Jörg, Brust Peter, Liu Boli, Jia Hongmei*. 99mTc-cyclopentadienyl tricarbonyl chelate-labeled compounds as selective sigma-2 receptor ligands for tumor imaging. Journal of Medicinal Chemistry, 2016, 59: 934-946.
8. Xie Fang, Bergmann Ralf, Kniess Torsten, Deuther-Conrad Winnie, Mamat Constantin, Neuber Christin, Liu Boli, Steinbach Jörg, Brust Peter, Pietzsch Jens, Jia Hongmei*.18F-labeled 1,4-dioxa-8-azaspiro[4.5]decane derivative: synthesis and biological evaluation of a s1 receptor radioligand with low lipophilicity as potent tumor imaging agent. Journal of Medicinal Chemistry, 2015, 58, 5395-5407.
9. Xie Fang, Kniess Torsten, Neuber Christin, Deuther-Conrad Winnie, Mamat Constantin, Lieberman Brian P., Liu Boli, Mach Robert H., Brust Peter, Steinbach Jörg, Pietzsch Jens, Jia Hongmei*. Novel indole-based sigma-2 receptor ligands: synthesis, structure–affinity relationship and antiproliferative activity. MedChemComm, 2015, 6, 1093-1103.
10. Wang Xia, Li Dan, Deuther-Conrad Winnie, Lu Jie, Xie Ying, Jia Bing, Cui Mengchao, Steinbach Jörg, Brust Peter, Liu Boli, Jia Hongmei*. Novel cyclopentadienyl tricarbonyl 99mTc complexes containing 1-piperonylpiperazine moiety: potential imaging probes for sigma-1 receptors. Journal of Medicinal Chemistry, 2014, 57, 7113-7125.
11. Chen Yuan-Yuan, Wang Xia, Zhang Jin-Ming, Deuther-Conrad Winnie, Zhang Xiao-Jun, Huang Yiyun, Li Yan, Ye Jia-Jun, Cui Meng-Chao, Steinbach Joerg, Brust Peter, Liu Bo-Li, Jia Hong-Mei*. Synthesis and evaluation of a 18F-labeled spirocyclic piperidine derivative as promising s1 receptor imaging agent. Bioorganic & Medicinal Chemistry, 2014, 22: 5270–5278.
12. Li Yan, Wang Xia, Zhang Jinming, Deuther-Conrad Winniw, Xie Fang, Zhang Xiaojun, Liu Jian, Qiao Jinping, Cui Mengchao, Steinbach Joerg, Brust Peter, Liu Boli, Jia Hongmei*. Synthesis and evaluation of novel 18F-labeled spirocyclic piperidine derivatives as σ1 receptor ligands for positron emission tomography imaging. Journal of Medicinal Chemistry, 2013, 56, 3478-3491.
Hong-Mei Jia
Professor and Supervisor for Ph.D. candidates, Ph. D. (Beijing Normal University), visiting scholar in Yale University, USA, visiting scholar and senior visiting scholar in Institute of Interdisciplinary Isotope Research, Leipzig, Germany, and senior visiting fellow in Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany. Editor of “Journal of Labelled Compounds and Radiopharmaceuticals” (the official journal of the International Isotope Society). Editorial Board Member of “Nuclear Medicine and Biology” (the official journal of Society of Radiopharmaceutical Sciences) and “EJNMMI Radiopharmacy and Chemistry”.
Postal address: College of Chemistry, Beijing Normal University,
No. 19 Xinjiekouwai Street, Beijing, 100875, China
Phone: +86-10-5880 7843; Fax: +86-10-5880 2750
E-mail: hmjia@bnu.edu.cn
Teaching
Radiopharmaceutical Chemistry, and General Chemistry Experiment.
Research Interests
Radiopharmaceutical chemistry, Development of new radiotracers and radiopharmaceuticals for imaging of biological functions.
Grants and research support
Current grants
Agency: National Natural Science Foundation of China (NSFC)
Grant No. 22276016
Title: Investigation on molecular probes targeted microglial colony-stimulating factor-1 receptor for neuroinflammation PET imaging
P.I.: Hongmei Jia
Project period: January 2023―December 2026
Agency: Beijing Natural Science Foundation
Grant No. 7212203
Title: 18F-Labeled sigma-1 receptor molecular probe and visualization of Alzheimer's disease progression
P.I.: Hongmei Jia
Project period: January 2021―December 2023
Agency: National Natural Science Foundation of China (NSFC)
Grant No. 21876013
Title: Investigation of sigma-2 receptor molecular probes for diagnosis of Alzheimer’s disease and efficacy monitoring of therapeutic strategies
P.I.: Hongmei Jia
Project period: January 2019―December 2022
Past grants
Agency: National Natural Science Foundation of China (NSFC)
Grant No. 21471019
Title: Investigation of Tc-99m/Re-188 labeled σ2 receptor radiopharmaceuticals for tumor imaging and therapy
P.I.: Hongmei Jia
Project period: January 2015―December 2018
Agency: National Natural Science Foundation of China (NSFC)
Grant No. 21071023
Title: Investigation of Tc-99m labeled σ2 receptor molecular probes for tumor imaging agents
P.I.: Hongmei Jia
Project period: January 2011―December 2013
Agency: National Natural Science Foundation of China (NSFC)
Grant No. 20501004
Title: Investigation of Tc-99m labeled σ receptor complexes for tumor imaging agents
P.I.: Hongmei Jia
Project period: January 2006―December 2008
Agency: State Education Ministry, P. R. China
Grant type: Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
Title: Reductive etherification reaction and its applications in the synthesis of F-18 labeled radiopharmaceuticals for PET imaging
P.I.: Hongmei Jia
Project period: 2004―2006
Invention Patents
1. Jia Hongmei, He Yingfang, Xie Fang, Lu Jie, Huang Yiyun. Preparation of [(tetrahydroxyfuranyl)methyl]piperazine compounds useful as sigma-1 receptor ligand. State Intellectual Property Office of the People’s Republic of China. ZL 2016 1 0509926.2 (Chinese), October 23, 2018.
2. Jia Hongmei, Wang Xia, Li Dan, Cui Mengchao, Liu Boli. Synthesis and applications of cyclopentadienyl tricarbonyl 99mTc/Re complexes as sigma-1 receptor ligands. State Intellectual Property Office of the People’s Republic of China. ZL 2013 1 0339656.1 (Chinese), April 6, 2016.
3. Jia Hongmei, Li Yan, Zhang Jinming, Cui Mengchao, Liu Boli. Synthesis and applications of 18F-labeled spirocyclic piperidine derivatives as σ1 receptor ligands. State Intellectual Property Office of the People’s Republic of China. ZL 2012 1 0097119.6 (Chinese), October 8, 2014.
Representative papers
1. Zhang Ying, Wang Tao, Zhang Xiaojun, Deuther-Conrad Winnie, Fu Hualong, Cui Mengchao, Zhang Jinming*, Brust Peter, Huang Yiyun*, Jia Hongmei*. Discovery and development of brain-penetrant 18F-labeled radioligands for neuroimaging of the sigma-2 receptors. Acta Pharmaceutica Sinica B, 2022, 12(3): 1406-1415.
2. Wang Tao, Zhang Ying, Zhang Xiaojun, Chen Leyuan, Zheng Ming-Qiang, Zhang Jinming*, Brust Peter, Deuther-Conrad Winnie, Huang Yiyun*, Jia Hongmei*. Synthesis and characterization of the two enantiomers of a chiral sigma-1 receptor radioligand: (S)-(+)- and (R)-(-)-[18F]FBFP. Chinese Chemical Letters, 2022, 33(7): 3543-3548.
3. Jia Hongmei*, Cai Zhengxin, Holden Daniel, He Yingfang, Lin Shu-fei, Li Songye, Baum Evan, Shirali Anupama, Kapinos Michael, Gao Hong, Ropchan Jim, Huang Yiyun*. Positron emission tomography imaging evaluation of a novel 18F-labeled sigma-1 receptor radioligand in cynomolgus monkeys. ACS Chemical Neuroscience, 2020, 11: 1673−1681.
4. Tian Jiale, He Yingfang, Deuther-Conrad Winnie, Fu Hualong, Xie Fang, Zhang Ying, Wang Tao, Zhang Xiaojun, Zhang Jinming*, Brust Peter, HuangYiyun, Jia Hongmei*. Synthesis and evaluation of new 1-oxa-8-azaspiro[4.5]decane derivatives as candidate radioligands for sigma-1 receptors. Bioorganic & Medicinal Chemistry, 2020, 28: 115560.
5． He Yingfang, Xie Fang, Ye Jiajun, Deuther-Conrad Winnie, Cui Bixiao, Wang Liang, Lu Jie, Steinbach Jörg, Brust Peter, Huang Yiyun, Lu Jie*, Jia Hongmei*. 1-(4-[18F]Fluorobenzyl)-4-((tetrahydrofuran-2-yl) methyl)piperazine: A novel suitable radioligand with low lipophilicity for imaging σ1 receptors in the brain. Journal of Medicinal Chemistry, 2017, 60: 4161-4172.
6. Wang Liang, Ye Jiajun, He Yingfang, Deuther-Conrad Winnie, Zhang Jinming, Zhang Xiaojun, Cui Mengchao*, Steinbach Jörg, Huang Yiyun, Brust Peter, Jia Hongmei*. 18F-Labeled indole-based analogs as highly selective radioligands for imaging sigma-2 receptors in the brain. Bioorganic & Medicinal Chemistry, 2017, 25: 3792–3802.
7. Li Dan, Chen Yuanyuan, Wang Xia, Deuther-Conrad Winnie, Chen Xin, Jia Bing, Dong Chengyan, Steinbach Jörg, Brust Peter, Liu Boli, Jia Hongmei*. 99mTc-cyclopentadienyl tricarbonyl chelate-labeled compounds as selective sigma-2 receptor ligands for tumor imaging. Journal of Medicinal Chemistry, 2016, 59: 934-946.
8. Xie Fang, Bergmann Ralf, Kniess Torsten, Deuther-Conrad Winnie, Mamat Constantin, Neuber Christin, Liu Boli, Steinbach Jörg, Brust Peter, Pietzsch Jens, Jia Hongmei*.18F-labeled 1,4-dioxa-8-azaspiro[4.5]decane derivative: synthesis and biological evaluation of a s1 receptor radioligand with low lipophilicity as potent tumor imaging agent. Journal of Medicinal Chemistry, 2015, 58, 5395-5407.
9. Xie Fang, Kniess Torsten, Neuber Christin, Deuther-Conrad Winnie, Mamat Constantin, Lieberman Brian P., Liu Boli, Mach Robert H., Brust Peter, Steinbach Jörg, Pietzsch Jens, Jia Hongmei*. Novel indole-based sigma-2 receptor ligands: synthesis, structure–affinity relationship and antiproliferative activity. MedChemComm, 2015, 6, 1093-1103.
10. Wang Xia, Li Dan, Deuther-Conrad Winnie, Lu Jie, Xie Ying, Jia Bing, Cui Mengchao, Steinbach Jörg, Brust Peter, Liu Boli, Jia Hongmei*. Novel cyclopentadienyl tricarbonyl 99mTc complexes containing 1-piperonylpiperazine moiety: potential imaging probes for sigma-1 receptors. Journal of Medicinal Chemistry, 2014, 57, 7113-7125.
11. Chen Yuan-Yuan, Wang Xia, Zhang Jin-Ming, Deuther-Conrad Winnie, Zhang Xiao-Jun, Huang Yiyun, Li Yan, Ye Jia-Jun, Cui Meng-Chao, Steinbach Joerg, Brust Peter, Liu Bo-Li, Jia Hong-Mei*. Synthesis and evaluation of a 18F-labeled spirocyclic piperidine derivative as promising s1 receptor imaging agent. Bioorganic & Medicinal Chemistry, 2014, 22: 5270–5278.
12. Li Yan, Wang Xia, Zhang Jinming, Deuther-Conrad Winniw, Xie Fang, Zhang Xiaojun, Liu Jian, Qiao Jinping, Cui Mengchao, Steinbach Joerg, Brust Peter, Liu Boli, Jia Hongmei*. Synthesis and evaluation of novel 18F-labeled spirocyclic piperidine derivatives as σ1 receptor ligands for positron emission tomography imaging. Journal of Medicinal Chemistry, 2013, 56, 3478-3491.
