讲授课程

物理化学B/ C(化学动力学基础和分子反应动力学章节)、化学基础实验II

研究兴趣

自由基和激发态是高反应活性的瞬态物种，是影响多种化学、生物过程的关键活泼中间体。我们致力于发展和运用多种时间分辨激光光谱技术，以能源、环境、材料和生命科学中的一些基础科学问题为背景，探测一系列重要的自由基及激发态分子的反应动力学过程，结合量子化学计算，深入阐述反应微观机理。研究方向主要包括生物分子DNA/蛋白质光响应、光催化有机合成反应等凝聚相体系中各种复杂的物理化学动态过程，涉及化学动力学、分子光化学、分子光生物、激光光谱等领域中的前沿基础。

主持项目

国家自然科学基金青年科学基金项目（主持，30万，2021.01 - 2023.12）

金沙威尼斯欢乐娱人城青年教师基金项目（主持，10万，2020.10 - 2022.09）

代表性论文

1. Chunfan Yang, Fang Wang, Qian Zhou, Jialong Jie*, and Hongmei Su*, Fluorescence Quenching Dynamics of 2-Amino-7-methyl-1,8-naphthyridine in Abasic-Site-Containing DNA Duplexes for Nucleobase Recognition, J. Phys. Chem. Lett. 2023, 14, 10585–10591.

2. Qian Zhou,# Wenwen Guo,# Zheng Hu, Shuyi Yan, Jialong Jie*, and Hongmei Su*, Can methylated purine bases act as photoionization hotspots?, Photochem. Photobio. 2023, 00: 1-12.

3. Zeqing Jiao, Chunfan Yang, Qian Zhou, Zheng Hu, Jialong Jie*, Xianwang Zhang, and Hongmei Su*, Sequence-specific binding behavior of coralyne toward triplex DNA: An ultrafast time-resolved fluorescence spectroscopy study, J. Chem. Phys. 2023, 158, 045101.

4. Zheng Hu, Qian Zhou, Zeqing Jiao, Peixuan Qin, Fei Wang, Ye Xia, Tianfeng Zhang, Jialong Jie*, and Hongmei Su*, Low Energy Photoionization of Phosphorothioate DNA-Oligomers and Ensuing Hole Transfer, J. Phys. Chem. B 2022, 126, 8699−8707.

5. Junjie Dong,# Chunhua Huang,# Shaoshi Guo,# Ye Xia, Yue Hou, Chunfan Yang, Xianwang Zhang, Jialong Jie*, Ben-zhan Zhu, and Hongmei Su*, Free-Radical-Mediated Photoinduced Electron Transfer between 6-Thioguanine and Tryptophan Leading to DNA-Protein-Like Cross-Link, J. Phys. Chem. B 2022, 126, 14−22.

6. Haihui Peng,# Jialong Jie,# Ifor P. Mortimer, Zehan Ma, Hongmei Su*, and Marc M. Greenberg*, Reactivity and DNA Damage by Independently Generated 2′-Deoxycytidin-N4-yl Radical, J. Am. Chem. Soc. 2021, 143, 14738–14747.

7. Xianwang Zhang, Jialong Jie*, Di Song*, and Hongmei Su, Deprotonation of Guanine Radical Cation G^+· Mediated by the Protonated Water Cluster. J. Phys. Chem. A 2020, 124, 6076-6083.

8. Jialong Jie, Ye Xia, Chunhua Huang, Hongmei Zhao, Chunfan Yang, Kunhui Liu, Di Song, BenZhan Zhu, and Hongmei Su*, Sulfur-centered Hemi-bond Radicals as Active Intermediates in S-DNA Phosphorothioate Oxidation. Nucleic Acids Res. 2019, 47, 11514-11526.

9. Jialong Jie, Kunhui Liu, Lidan Wu, Hongmei Zhao, Di Song, and Hongmei Su*, Capturing the Radical Ion-pair Intermediate in DNA Guanine Oxidation. Sci. Adv. 2017, 3, e1700171.

10. Jialong Jie, Chen Wang, Hongmei Zhao, Di Song*, and Hongmei Su*, Experimental and Theoretical Study of the Deprotonation of DNA Adenine Cation Radical. Chin. J. Chem. Phys. 2017, 30, 664.

11. Zheng Hu,# Danfeng Wang,# Qian Zhou, Jialong Jie, and Hongmei Su*, Complexed Photosensitizer of Hypericin with G‑Quadruplex: Structure-Dependent Behavior, J. Phys. Chem. B 2024, 128, 576−584.

12. Qian Zhou,# Tianfeng Zhang,# Jialong Jie, Yue Hou, Zheng Hu, Zeqing Jiao, and Hongmei Su*, TiO₂ as a Nanozyme Mimicking Photolyase to Repair DNA Damage, J. Phys. Chem. Lett. 2022, 13, 10929–10935.

13. Qian Zhou, Yinghui Wang, Xiaojuan Dai, Chunfan Yang, Jialong Jie, and Hongmei Su*, One-electron oxidation of TAT-motif triplex DNA and the ensuing Hoogsteen hydrogen-bonding dissociation. J. Chem. Phys. 2020, 152, 035101.

14. Yinghui Wang, Hongmei Zhao, Chunfan Yang, Jialong Jie, Xiaojuan Dai, Qian Zhou, Kunhui Liu, Di Song, and Hongmei Su*, Degradation of cytosine radical cations in 2’-deoxycytidine and in i-motif DNA: hydrogen-bonding guided pathways. J. Am. Chem. Soc. 2019, 141, 1970–1979.

15. Huaning Zhu, Meng Li, Jiangpu Hu, Xian Wang, Jialong Jie, Qianjin Guo, Chuanfeng Chen, and Andong Xia*, Ultrafast Investigation of Intramolecular Charge Transfer and Solvation Dynamics of Tetrahydro[5]-helicene-Based Imide Derivatives. Sci. Rep. 2016, 6:24313.

16. Lidan Wu, Kunhui Liu, Jialong Jie, Di Song, and Hongmei Su*, Direct Observation of Guanine Radical Cation Deprotonation in G-quadruplex DNA. J. Am. Chem. Soc. 2015, 137, 259-266.