讲授课程

物理化学，数学物理方法，化学测量与计算实验

研究兴趣

生物体系和软物质体系自组装的多尺度动力学模拟

科研项目

1. 膜弯曲的产生机制及其对蛋白质吸附的影响，国家自然科学基金面上项目，2017年-2020年，65万
2. 多层次自组装的多尺度模拟，国家自然科学基金面上项目，2014年-2017年，80万
3. 脂筏介导的跨膜信号传递的理论模拟，国家自然科学基金重大研究计划培育项目，2012年-2015年，65万
4. 抗菌肽和生物膜相互作用的耗散粒子动力学研究，国家自然科学基金面上项目，2009年-2011年，30万

代表性论文

1. Formation Mechanism and Properties of Polyelectrolyte Multilayer-Supported ipid Bilayers: A Coarse-Grained Molecular Dynamics Study, Caixia Wen, † Mingwei Wan, † Xiaoxu Li, † Qiang He, ‡ Lianghui Gao,* ,† and Weihai Fang, ACS Omega 2, 910 ( 2017).
2. Self-assembly of gold nanorods coated with phospholipids: a coarse-grained molecular dynamics study，Mingwei Wan, Xiaoxu Li, Lianghui Gao,* and Weihai Fang，Nanotechnology 27, 465704 (2016).
3. Dissipative Particle Dynamics Simulations for Phospholipid Membranes Based on a Four-To-One Coarse-Grained Mapping Scheme, Xiaoxu Li, Lianghui Gao,* and Weihai Fang, PLOS ONE 11, 0154568 (2016).
4. Mechanism of Inhibition of Human Islet Amyloid Polypeptide-Induced Membrane Damage by a Small Organic Fluorogen，Xiaoxu Li, Minwei Wan, Lianghui Gao,* and Weihai Fang, Sci. Rep. 6, 21614 (2016).
5. Nanodomain Formation of Ganglioside GM1 in Lipid Membrane: Effects of Cholera Toxin-Mediated Cross-Linking, Huijiao Sun, Licui Chen, Lianghui Gao,* and Weihai Fang, Langmuir 31, 9105 (2015).
6. Theoretical Insight into the Relationship between the Structures of Antimicrobial Peptides and Their Actions on Bacterial Membranes, Licui Chen, Xiaoxu Li, Lianghui Gao,* and Weihai Fang, J. Phys. Chem. B 119, 850 (2015).
7. Effects of Antimicrobial Peptide Revealed by Simulations: Translocation versus Membrane Corrugation, Licui Chen, Nana Jia, Lianghui Gao*, Weihai Fang, and L. Golubovic, Int. J. Mol. Sci. 14, 7932 (2013).
8. The folding dynamics and infrared spectra of a photocleabaged tetrapeptide predicted by theoretical simulations, Tiantian Jiao, Lianghui Gao,* Xuebo Chen, and Weihai Fang, J. Phys. Chem. B 116, 14318 (2012).
9. How the antimicrobial peptides kill bacteria: computational physics insights, Licui Chen, Lianghui Gao*, Weihai Fang, and L. Golubovic, Commun. Comput. Phys. 11, 709 (2012).
10. Semi-bottom-up coarse graining of water based on microscopic simulations, Lianghui Gao* and W. Fang, J. Chem. Phys. 135, 184101 (2011).
11. Self-Assembly of Lamellar Lipid-DNA Complexes Simulated by Explicit Solvent Counterion Model，Lianghui Gao*, Jun Cao, and Weihai Fang, J. Phys. Chem. B 114, 7261 (2010).
12. Theoretical Insight into the Photodegradation of a Disulfide Bridged Cyclic Tetrapeptide in Solution and Subsequent Fast Unfolding-Refolding Events,  Xuebo Chen, Lianghui Gao, Weihai Fang, et al, J. Phys. Chem. B 114, 15 (2010).
13. Communications: Self-energy and corresponding virial contribution of electrostatic interactions in dissipative particle dynamics: Simulations of cationic lipid bilayers, Lianghui Gao* and W. Fang, J. Chem. Phys. 132, 031102 (2010).