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牛丽亚 |
副教授,博士生导师,理学博士 |
通信地址:北京市新街口外大街19号 金沙威尼斯欢乐娱人城918A 邮编:100875 电话:010 5880 6828 |
电子邮箱:niuly@bnu.edu.cn |
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研究兴趣
新型有机荧光探针与诊疗试剂的设计合成及生物应用
课题组主页:https://www.x-mol.com/groups/qingzheng_yang
学习工作经历
2019.09–至今:金沙威尼斯欢乐娱人城,金沙威尼斯欢乐娱人城,副教授
2016.04–2019.08:金沙威尼斯欢乐娱人城,金沙威尼斯欢乐娱人城,讲师
2013.07–2016.03:中国科学院理化技术研究所,助理研究员
2010.09– 2013.06:中国科学院理化技术研究所,博士(导师: 杨清正)
2007.09– 2010.03:北京航空航天大学化学与环境学院,硕士 (导师: 郭林、张东凤)
2003.09– 2007.06:北京航空航天大学材料科学与工程学院,学士
代表性论文
1. Kun-Xu Teng, Li-Ya Niu* and Qing-Zheng Yang*, Supramolecular Photosensitizer Enables Oxygen-Independent Generation of Hydroxyl Radicals for Photodynamic Therapy, J. Am. Chem. Soc. 2023, 145, 4081-4087.
2. Dongsheng Zhang, Kun-Xu Teng, Luyang Zhao, Li-Ya Niu* and Qing-Zheng Yang*, Ultra-small Nano-assemblies as Tumor-targeted and Renal Clearable Theranostic Agent for Photodynamic Therapy, Adv. Mater. 2023, DOI: 10.1002/adma.202209789.
3. Dongsheng Zhang†, Ling-Ya Peng†, Kun-Xu Teng, Li-Ya Niu*, Ganglong Cui*, and Qing-Zheng Yang*, Self-Assembly Regulated Singlet Oxygen Generation of Heavy-Atom-Free Organic Chromophores, ACS Materials Lett. 2023, 5, 180-188.
4. Xiao-Xiao Chen†, Yufei Wu†, Xiaoxiao Ge, Liandi Lei, Li-Ya Niu*, Qing-Zheng Yang* and Lemin Zheng*, In Vivo Imaging of Heart Failure with Preserved Ejection Fraction by Simultaneous Monitoring of Cardiac Nitric Oxide and Glutathione Using a Three-channel Fluorescent Probe, Biosens. Bioelectron., 2022, 214, 114510.
5. Yan-Fei Kang, Wen-Kai Chen, Kun-Xu Teng, Ling-Yun Wang, Xiao-Cheng Xu, Li-Ya Niu,* Ganglong Cui* and Qing-Zheng Yang*, Aggregation turns BODIPY fluorophores into photosensitizers: reversibly switching intersystem crossing on-and-off for smart photodynamic therapy, CCS Chem, 2022, 4, 3516-3528.
6. Xiao-Xiao Chen, Li-Ya Niu* and Qing-Zheng Yang*, Visualizing the Underlying Signaling Pathway Related to Nitric Oxide and Glutathione in Cardiovascular Disease Therapy by a Sequentially Activated Fluorescent Probe, Anal. Chem., 2021, 93, 3922-3928.
7. Kun-Xu Teng, Li-Ya Niu,* Yan-Fei Kang, and Qing-Zheng Yang,* Rational Design of a “Dual Lock-and-Key” Supramolecular Photosensitizer Based on Aromatic Nucleophilic Substitution for Specific and Enhanced Photodynamic Therapy, Chem. Sci., 2020, 11, 9703–9711.
8. Xin Zhu, Jian-Xin Wang, Li-Ya Niu,* Qing-Zheng Yang*, Aggregation-Induced Emission Materials with Narrowed Emission Band by Light-Harvesting Strategy: Fluorescence and Chemiluminescence Imaging, Chem. Mater. 2019, 31, 3573-358.
9. Xiao-Xiao Chen, Li-Ya Niu,* Qing-Zheng Yang*, BODIPY-Based Fluorescent Probe for Dual-Channel Detection of Nitric Oxide and Glutathione: Visualization of Cross-Talk in Living Cells, Anal. Chem. 2019, 91, 4301−4306.
10. Li-Ya Niu, Yu-Zhe Chen, Hai-Rong Zheng, Li-Zhu Wu, Chen-Ho Tung and Qing-Zheng Yang*, Design Strategies of Fluorescent Probes for Selective Detection Among Biothiols, Chem. Soc. Rev. 2015, 44, 6143-6160.
11. Li-Ya Niu, Ying-Shi Guan, Yu-Zhe Chen, Li-Zhu Wu, Chen-Ho Tung and Qing-Zheng Yang* BODIPY-Based Ratiometric Fluorescent Sensor for Highly Selective Detection of Glutathione over Cysteine and Homocysteine J. Am. Chem. Soc. 2012, 134, 18928−18931.